SOME NEW REACTIONS AND DERIVATIVES OF KOJIC ACID

Kojic Acid Derivatives

Melanin is one of the most important pigments which exist ubiquitously from microorganisms to plants and animals. It is secreted by melanocyte cells and determines the color of skin and hair in mammalians. It protects the skin from photocarcinogenesis by absorbing UV sunlight and removing reactive oxygen species (ROS) (Gupta, 2006; Kim, 2005; Sapkota, 2011). It is formed by enzymatically cataly...

Reactions of some new thienothiophene derivatives.

Facile and convenient syntheses of bisdimethylthieno[2,3-b]thiophen-2,5-diyl bis(oxazole-2-amine), bis(1H-imidazol-2-amine), bis((3a)-H-indole),[1,2-a]pyrimidine), bis(1H-imidazo[1,2-b][1,2,4]triazole) and bis(9H-benzo[d]imidazo[1,2-a]imidazole) derivatives incorporating a thieno[2,3-b]thiophene moiety from the versatile and readily accessible 1,1'(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)-b...

In vitro and in silico studies of the inhibitory effects of some novel kojic acid derivatives on tyrosinase enzyme

Objective(s): Tyrosinase is a key enzyme in pigment synthesis. Overproduction of melanin in parts of the skin results in hyperpigmentation diseases. This enzyme is also responsible for the enzymatic browning in fruits and vegetables. Thus, its inhibitors are of great importance in the medical, cosmetic and agricultural fields. Materials and Methods: A series of twelve kojic acid derivatives wer...

Stereoselective radical reactions of some tartaric and glyceric acid derivatives.

[reaction: see text] Free radicals generated by the decarboxylation of dimethoxydioxanecarboxylic acids derived from L-(+)-tartaric acid and L-glyceric acid added to some maleimides and acrylates with high stereoselectivity. This method provides easy access to some chiral building blocks.

synthesis and anti-tyrosinase evaluation of some novel derivatives of kojic acid